Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.61 |
| ▸ | APP | P05067 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27550091 | 0.85 | MAOB (0.80) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL11426612 | 0.81 | MAOB (0.67) | MAOBF2KCNH2GRIN2B | |
| SCHEMBL13764324 | 0.80 | APP (0.61) | MAOBAPPSMN1; SMN2CA12CA1 | |
| SCHEMBL171320 | 0.80 | MAOB (0.54) | MAOBAPPSMN1; SMN2PARP10F2 | |
| SCHEMBL11426766 | 0.80 | MAOB (0.61) | MAOBAPPSMN1; SMN2NR4A2F2 | |
| SCHEMBL953509 | 0.79 | F2 (0.65) | MAOBAPPSMN1; SMN2NR4A2F2 | |
| SCHEMBL6927496 | 0.79 | MAOB (0.66) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL18937890 | 0.79 | MAOB (0.71) | MAOBAPPNR4A2CA12CA1 | |
| SCHEMBL14156909 | 0.79 | IDO1 (0.50) | MAOBAPPSMN1; SMN2EPHX2NPC1 | |
| SCHEMBL20804354 | 0.79 | MAOB (0.67) | MAOBAPPNR4A2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073925-B2 | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof | ALBANY MOLECULAR RESEARCH, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| EP-2558094-A1 | PYRIDONE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011130086-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011127643-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-10-20 | — | — | WO | disclosed |