Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.48 |
| ▸ | WEE1 | P30291 | 11/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | GSK3A | P49840 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2550135 | 0.99 | CHEK1 (0.47) | CHEK1WEE1CDK5DYRK1AGSK3A | |
| SCHEMBL2564831 | 0.85 | CHEK1 (0.47) | CHEK1WEE1CDK5DYRK1AGSK3A | |
| SCHEMBL2552481 | 0.83 | CHEK1 (0.45) | CHEK1WEE1CDK5DYRK1AGSK3A | |
| Hydrochloric Acid SCHEMBL15092457 | 0.83 | CHEK1 (0.45) | CHEK1WEE1CDK5DYRK1AGSK3A | |
| SCHEMBL2574942 | 0.81 | WEE1 (0.53) | CHEK1WEE1CDK2PRKCQMEN1 | |
| SCHEMBL2550354 | 0.81 | CHEK1 (0.45) | CHEK1WEE1CDK5DYRK1AGSK3A | |
| SCHEMBL2551422 | 0.81 | WEE1 (0.51) | CHEK1WEE1CDK5DYRK1AGSK3A | |
| SCHEMBL2550191 | 0.79 | CHEK1 (0.42) | CHEK1WEE1CDK5DYRK1AGSK3A | |
| SCHEMBL2546633 | 0.77 | NR1I2 (0.49) | CHEK1WEE1CDK5DYRK1AGSK3A | |
| SCHEMBL2549922 | 0.75 | MAP2K7 (0.47) | CHEK1WEE1CDK5DYRK1AGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552206-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123419-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-10-06 | — | — | WO | disclosed |