Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.34 |
| ▸ | CCR8 | P51685 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12265590 | 0.83 | PDE4A (0.39) | AKT1AKT2MAPK13MAPK12MAPK11 | |
| SCHEMBL2576817 | 0.74 | PIK3CD (0.44) | PIK3CA | |
| SCHEMBL12196977 | 0.73 | DYRK1A (0.36) | AKT1AKT2MAPK13MAPK12MAPK11 | |
| SCHEMBL2508774 | 0.73 | DYRK1A (0.36) | AKT1AKT2MAPK13MAPK12MAPK11 | |
| SCHEMBL2545743 | 0.71 | KLK7 (0.41) | HRH1AKT1AKT2KDM4ELMNA | |
| Dipyridyl SCHEMBL16445111 | 0.64 | KDM4E (0.74) | HRH1KDM4ELMNACCR1CCR5 | |
| Dipyridyl SCHEMBL17315016 | 0.62 | KDM4E (0.70) | HRH1KDM4ELMNACCR1CCR5 | |
| Dipyridyl SCHEMBL10405168 | 0.62 | KDM4E (0.70) | HRH1KDM4ELMNACCR1CCR5 | |
| SCHEMBL24697495 | 0.62 | KDM4E (0.50) | KDM4ELMNACCR1CCR5CCR8 | |
| SCHEMBL31540362 | 0.62 | KDM4E (0.50) | KDM4ELMNACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552908-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |