Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15024592 | 1.00 | BACE1 (0.41) | BACE1PDK1PDK2PDK3PDK4 | |
| SCHEMBL7713454 | 0.90 | BACE1 (0.43) | BACE1PDK1PDK2PDK3PDK4 | |
| SCHEMBL2552556 | 0.90 | BACE1 (0.43) | BACE1PDK1PDK2PDK3PDK4 | |
| SCHEMBL15024588 | 0.88 | BACE1 (0.42) | BACE1PDK1PDK2PDK3PDK4 | |
| SCHEMBL2557967 | 0.88 | BACE1 (0.42) | BACE1PDK1PDK2PDK3PDK4 | |
| SCHEMBL15011230 | 0.86 | BACE1 (0.40) | BACE1METAP2 | |
| SCHEMBL14685922 | 0.86 | BACE1 (0.40) | BACE1METAP2 | |
| SCHEMBL14686409 | 0.86 | BACE1 (0.40) | BACE1METAP2 | |
| SCHEMBL7715363 | 0.84 | BACE1 (0.37) | BACE1 | |
| SCHEMBL2576349 | 0.83 | BACE1 (0.43) | BACE1PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011125006-A2 | NOVEL SULTAM COMPOUNDS | PFIZER INC. (US) | 2011-10-13 | — | — | WO | disclosed |