⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1561 | 1.00 | — | — | |
| SCHEMBL8829599 | 0.93 | — | — | |
| SCHEMBL3963367 | 0.93 | — | — | |
| SCHEMBL135172 | 0.93 | — | — | |
| SCHEMBL224443 | 0.93 | — | — | |
| SCHEMBL25405176 | 0.93 | — | — | |
| SCHEMBL133773 | 0.93 | — | — | |
| SCHEMBL22092371 | 0.93 | — | — | |
| SCHEMBL21409672 | 0.93 | — | — | |
| SCHEMBL1196383 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481575-B2 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2013-07-09 | — | — | US | disclosed |
| EP-1386922-B1 | Synthesis of epothilones, intermediates thereof, analogues and uses thereof | SLOAN KETTERING INST CANCER (US) | 2012-04-11 | — | — | EP | disclosed |
| US-20110263663-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-10-27 | — | — | US | disclosed |
| US-RE41990-E1 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-12-07 | — | — | US | disclosed |
| US-20100240721-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-23 | — | — | US | disclosed |
| US-7750164-B2 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-07-06 | — | — | US | disclosed |
| US-20080004450-A1 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-01-03 | — | — | US | disclosed |
| US-6972335-B2 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2005-12-06 | — | — | US | disclosed |
| US-6965034-B2 | Synthesis of epothilones, intermediates thereto and analogues thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2005-11-15 | — | — | US | disclosed |
| EP-1058679-B1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEROF | SLOAN KETTERING INST CANCER (US) | 2005-10-19 | — | — | EP | disclosed |
| US-6300355-B1 | FOR THERAPY OF CANCER | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2001-10-09 | — | — | US | disclosed |
| US-6284781-B1 | ANTICANCER AGENT | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2001-09-04 | — | — | US | disclosed |
| US-6242469-B1 | ANTICARCINOGENIC AGENTS FOR MULTIDRUG RESISTANT CELLS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2001-06-05 | — | — | US | disclosed |
| EP-0977563-A4 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | SLOAN KETTERING INST CANCER (US) | 2001-04-25 | — | — | EP | disclosed |
| US-6204388-B1 | USING BLOCKING AGENT | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2001-03-20 | — | — | US | disclosed |
| EP-1058679-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEROF | Sloan-Kettering Institute For Cancer Research (US) | 2000-12-13 | — | — | EP | disclosed |
| EP-0977563-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | Sloan-Kettering Institute For Cancer Research (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1999043653-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEROF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1999-09-02 | — | — | WO | disclosed |
| WO-1999001124-A9 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | SLOAN KETTERING INST CANCER (US) | 1999-05-14 | — | — | WO | disclosed |
| WO-1999001124-A1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1999-01-14 | — | — | WO | disclosed |