Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16103438 | 0.91 | MAPK14 (0.49) | GRM2MAPK14HSD11B1ALDH1A1KDM4E | |
| SCHEMBL5662280 | 0.85 | KDM4E (0.43) | GRM2MAPK14HSD11B1ALDH1A1KDM4E | |
| SCHEMBL12185196 | 0.83 | PIM1 (0.46) | GRM2MAPK14ALDH1A1KDM4E | |
| SCHEMBL1914524 | 0.82 | MAPK1 (0.45) | GRM2MAPK14MAPK1 | |
| SCHEMBL30397855 | 0.82 | MAPK14 (0.42) | GRM2MAPK14HSD11B1ALDH1A1KDM4E | |
| SCHEMBL13216313 | 0.79 | KDM4E (0.44) | GRM2MAPK14ALDH1A1KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL20959623 | 0.76 | KDM4E (0.39) | GRM2MAPK14ALDH1A1KDM4EKMT2A | |
| SCHEMBL3620225 | 0.76 | GRM2 (0.58) | GRM2MAPK14HSD11B1NR1I2NPC1 | |
| SCHEMBL15007180 | 0.73 | MAPK14 (0.60) | GRM2MAPK14HSD11B1 | |
| SCHEMBL15013661 | 0.73 | GRM2 (0.43) | GRM2MAPK14HSD11B1ALDH1A1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |