Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.82 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.82 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.63 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
| ▸ | G6PD | P11413 | 10/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877050 | 1.00 | GRIN1 (0.82) | GRIN1GRIN2BNR1I3BCHEACHE | |
| SCHEMBL18541401 | 1.00 | GRIN1 (0.82) | GRIN1GRIN2BNR1I3BCHEACHE | |
| SCHEMBL19253215 | 0.88 | GRIN1 (0.83) | GRIN1GRIN2BNR1I3BCHEACHE | |
| SCHEMBL19253287 | 0.88 | GRIN1 (0.83) | GRIN1GRIN2BNR1I3BCHEACHE | |
| SCHEMBL19733241 | 0.88 | GRIN1 (0.83) | GRIN1GRIN2BNR1I3BCHEACHE | |
| SCHEMBL11313537 | 0.83 | GRIN1 (0.71) | GRIN1GRIN2BNR1I3BCHEACHE | |
| SCHEMBL14122743 | 0.82 | GRIN1 (0.73) | GRIN1GRIN2BNR1I3BCHEACHE | |
| SCHEMBL19253335 | 0.82 | GRIN1 (0.73) | GRIN1GRIN2BNR1I3BCHEACHE | |
| SCHEMBL12646012 | 0.82 | GRIN1 (0.73) | GRIN1GRIN2BNR1I3BCHEACHE | |
| SCHEMBL12646120 | 0.82 | GRIN1 (0.73) | GRIN1GRIN2BNR1I3BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3581563-B1 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIV OF NEW YORK (US) | 2023-06-28 | — | — | EP | disclosed |
| US-20220162254-A1 | SHIP INHIBITORS AND USES THEREOF | UNIV NEW YORK STATE RES FOUND (US) | 2022-05-26 | — | — | US | disclosed |
| US-20220162254-A1 | SHIP INHIBITORS AND USES THEREOF | UNIV NEW YORK STATE RES FOUND (US) | 2022-05-26 | — | — | US | disclosed |
| US-11319336-B2 | Ship inhibitors and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2022-05-03 | — | — | US | disclosed |
| US-11319336-B2 | Ship inhibitors and uses thereof | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 2022-05-03 | — | — | US | disclosed |
| US-20220023315-A1 | METHODS OF ACTIVATING MICROGLIAL CELLS | UNIV NEW YORK STATE RES FOUND (US) | 2022-01-27 | — | — | US | disclosed |
| US-20220023315-A1 | METHODS OF ACTIVATING MICROGLIAL CELLS | UNIV NEW YORK STATE RES FOUND (US) | 2022-01-27 | — | — | US | disclosed |
| EP-3829589-A1 | METHODS OF ACTIVATING MICROGLIAL CELLS | The Research Foundation for the State University of New York (US) | 2021-06-09 | — | — | EP | disclosed |
| US-20200376005-A1 | SHIP INHIBITION TO COMBAT OBESITY | The Research Foundation for the State of University of New York | 2020-12-03 | — | — | US | disclosed |
| EP-3695841-A2 | SHIP INHIBITION TO COMBAT OBESITY | The Research Foundation for the State University of New York (US) | 2020-08-19 | — | — | EP | disclosed |
| US-20160129017-A1 | SHIP INHIBITION TO COMBAT OBESITY | The Research Foundation for the State University New York (US) | 2016-05-12 | — | — | US | disclosed |
| EP-3016660-A1 | SHIP INHIBITION TO COMBAT OBESITY | The Research Foundation for the State University of New York (US) | 2016-05-11 | — | — | EP | disclosed |
| WO-2015003003-A1 | SHIP INHIBITION TO COMBAT OBESITY | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2015-01-08 | — | — | WO | disclosed |
| WO-2015003003-A1 | SHIP INHIBITION TO COMBAT OBESITY | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2015-01-08 | — | — | WO | disclosed |
| US-20130102577-A1 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 2013-04-25 | — | — | US | disclosed |
| US-20130102577-A1 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 2013-04-25 | — | — | US | disclosed |
| US-20130102577-A1 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 2013-04-25 | — | — | US | disclosed |
| EP-2556055-A2 | SHIP INHIBITORS AND USES THEREOF | The Research Foundation of the State University of New York (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011127465-A2 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011127465-A2 | SHIP INHIBITORS AND USES THEREOF | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 2011-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200376005-A1 | SHIP INHIBITION TO COMBAT OBESITY | PPM1G, PPM1B, PPM1F | GRIN1 3075/4885GRIN2B 4128/4885NR1I3 1512/4885 |
| US-20130102577-A1 | SHIP INHIBITORS AND USES THEREOF | PPP5C, DUSP1, DUSP5 | GRIN1 3595/4885GRIN2B 4457/4885NR1I3 1601/4885 |
| US-11319336-B2 | Ship inhibitors and uses thereof | PPP5C, DUSP1, DUSP5 | GRIN1 3595/4885GRIN2B 4457/4885NR1I3 1601/4885 |
| US-20220023315-A1 | METHODS OF ACTIVATING MICROGLIAL CELLS | LPCAT3, PLAAT2, PLA2G4B | GRIN1 467/4885GRIN2B 432/4885NR1I3 3291/4885 |
| US-20220162254-A1 | SHIP INHIBITORS AND USES THEREOF | PPP5C, DUSP1, DUSP5 | GRIN1 3595/4885GRIN2B 4457/4885NR1I3 1601/4885 |
| US-20160129017-A1 | SHIP INHIBITION TO COMBAT OBESITY | PPM1G, PPM1B, PPM1F | GRIN1 3075/4885GRIN2B 4128/4885NR1I3 1512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.