Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.39 |
| ▸ | CDK2 | P24941 | 7/20 | 0.39 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 4/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.39 |
| ▸ | CCND1 | P24385 | 4/20 | 0.39 |
| ▸ | CCND3 | P30281 | 4/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CDK7 | P50613 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | CCNH | P51946 | 3/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30810412 | 0.82 | CDK1 (0.51) | LRRK2RXFP1CCNE1CDK2CDK1 | |
| SCHEMBL30837013 | 0.80 | LRRK2 (0.47) | LRRK2CCNE1CDK2CDK1CDK4 | |
| SCHEMBL27229135 | 0.80 | LRRK2 (0.47) | LRRK2CCNE1CDK2CDK1CDK4 | |
| SCHEMBL30291199 | 0.79 | KDM5B (0.41) | LRRK2RXFP1CCNE1CDK2CDK1 | |
| SCHEMBL30810528 | 0.77 | CDK1 (0.54) | RXFP1CCNE1CDK2CDK1CDK4 | |
| SCHEMBL14648923 | 0.77 | RXFP1 (0.59) | RXFP1NTRK1 | |
| SCHEMBL30291351 | 0.76 | CCNE1 (0.43) | RXFP1CCNE1CDK2CDK1CDK4 | |
| SCHEMBL30291251 | 0.76 | CDK1 (0.41) | RXFP1CCNE1CDK2CDK1CDK4 | |
| SCHEMBL21596308 | 0.75 | PIK3CD (0.47) | LRRK2 | |
| SCHEMBL30379895 | 0.75 | PIK3CD (0.47) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |