Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 20/20 | 0.50 |
| ▸ | AKT1 | P31749 | 19/20 | 0.50 |
| ▸ | AKT2 | P31751 | 15/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3948594 | 0.99 | AKT3 (0.49) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL3948624 | 0.89 | AKT3 (0.59) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL2367270 | 0.82 | AKT1 (0.60) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| SCHEMBL2556079 | 0.82 | AKT1 (0.60) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| Hydrochloric Acid SCHEMBL15390326 | 0.82 | AKT1 (0.59) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| Hydrochloric Acid SCHEMBL2554899 | 0.82 | AKT1 (0.59) | AKT3AKT1AKT2PIK3CAPRKG1 | |
| Hydrochloric Acid SCHEMBL4360899 | 0.81 | AKT1 (0.57) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL2573814 | 0.79 | AKT1 (0.52) | AKT3AKT1AKT2 | |
| SCHEMBL3947910 | 0.77 | RPS6KB1 (0.39) | AKT3AKT1AKT2 | |
| SCHEMBL192662 | 0.76 | AKT3 (0.83) | AKT3AKT1AKT2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558864-A1 | FOX03A AS PREDICTIVE BIOMARKER FOR PI3K/AKT KINASE PATHWAY INHIBITOR EFFICACY | Genentech, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011130654-A1 | FOX03A AS PREDICTIVE BIOMARKER FOR PI3K/AKT KINASE PATHWAY INHIBITOR EFFICACY | GENENTECH, INC. (US) | 2011-10-20 | — | — | WO | disclosed |