Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.61 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.42 |
| ▸ | CCR3 | P51677 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30451332 | 1.00 | NR1H2 (0.61) | NR1H2NR1H3PDK2CCR3HRH1 | |
| SCHEMBL22310517 | 1.00 | NR1H2 (0.61) | NR1H2NR1H3PDK2CCR3HRH1 | |
| SCHEMBL30451002 | 0.89 | NR1H2 (0.51) | NR1H2NR1H3PDK2CCR3HRH1 | |
| SCHEMBL20060823 | 0.89 | NR1H2 (0.51) | NR1H2NR1H3PDK2CCR3HRH1 | |
| SCHEMBL20068703 | 0.89 | NR1H2 (0.51) | NR1H2NR1H3PDK2CCR3HRH1 | |
| SCHEMBL18872709 | 0.87 | NR1H2 (0.80) | NR1H2NR1H3PDK2MEN1KMT2A | |
| SCHEMBL20538904 | 0.87 | NR1H2 (0.80) | NR1H2NR1H3PDK2MEN1KMT2A | |
| SCHEMBL18872696 | 0.87 | NR1H2 (0.80) | NR1H2NR1H3PDK2MEN1KMT2A | |
| SCHEMBL20061086 | 0.86 | NR1H2 (0.53) | NR1H2NR1H3PDK2CCR3HRH1 | |
| SCHEMBL30451551 | 0.86 | NR1H2 (0.53) | NR1H2NR1H3PDK2CCR3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11655216-B2 | Aryl and heteroaryl ether derivatives as liver X receptor beta agonists, compositions, and their use | MERCK SHARP & DOHME LLC (US) | 2023-05-23 | — | — | US | disclosed |
| US-11655216-B2 | Aryl and heteroaryl ether derivatives as liver X receptor beta agonists, compositions, and their use | MERCK SHARP & DOHME LLC (US) | 2023-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11655216-B2 | Aryl and heteroaryl ether derivatives as liver X receptor beta agonists, compositions, and their use | NR1H2, NR1H3, NR1H4 | NR1H2 1/4885NR1H3 2/4885PDK2 2381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.