Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 15/20 | 0.36 |
| ▸ | AKT2 | P31751 | 15/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 15/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557651 | 1.00 | AKT1 (0.36) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL12813058 | 0.90 | AKT1 (0.38) | AKT1AKT2AKT3 | |
| SCHEMBL2554086 | 0.90 | AKT1 (0.38) | AKT1AKT2AKT3 | |
| SCHEMBL2552239 | 0.86 | AKT2 (0.41) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL15973218 | 0.82 | AKT1 (0.36) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL17022987 | 0.78 | AKT1 (0.43) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2557757 | 0.75 | AKT1 (0.51) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191678 | 0.75 | AKT1 (0.50) | AKT1AKT2AKT3 | |
| SCHEMBL675548 | 0.75 | AKT1 (0.50) | AKT1AKT2AKT3 | |
| SCHEMBL17022986 | 0.75 | AKT1 (0.50) | AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558864-A1 | FOX03A AS PREDICTIVE BIOMARKER FOR PI3K/AKT KINASE PATHWAY INHIBITOR EFFICACY | Genentech, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011130654-A1 | FOX03A AS PREDICTIVE BIOMARKER FOR PI3K/AKT KINASE PATHWAY INHIBITOR EFFICACY | GENENTECH, INC. (US) | 2011-10-20 | — | — | WO | disclosed |