Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 18/20 | 0.65 |
| ▸ | GUCY1B1 | Q02153 | 18/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.65 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16694902 | 0.90 | GUCY1A1 (0.65) | GUCY1A1GUCY1B1KCNH2PDE5ACYP2C9 | |
| SCHEMBL2520175 | 0.86 | GUCY1A1 (0.82) | GUCY1A1GUCY1B1KCNH2PDE5ACYP2C9 | |
| SCHEMBL2446691 | 0.84 | GUCY1A1 (0.61) | GUCY1A1GUCY1B1KCNH2PDE5ACYP2C9 | |
| SCHEMBL2438767 | 0.84 | GUCY1A1 (0.61) | GUCY1A1GUCY1B1KCNH2PDE5ACYP2C9 | |
| SCHEMBL14481485 | 0.84 | GUCY1A1 (0.64) | GUCY1A1GUCY1B1KCNH2PDE5ACYP2C9 | |
| SCHEMBL2448251 | 0.83 | GUCY1A1 (0.63) | GUCY1A1GUCY1B1KCNH2PDE5ACYP2C9 | |
| SCHEMBL2455410 | 0.82 | GUCY1A1 (0.63) | GUCY1A1GUCY1B1KCNH2PDE5ACYP2C9 | |
| SCHEMBL2438739 | 0.81 | GUCY1A1 (0.72) | GUCY1A1GUCY1B1KCNH2PDE5A | |
| SCHEMBL14481707 | 0.80 | GUCY1A1 (0.62) | GUCY1A1GUCY1B1KCNH2PDE5ACYP2C9 | |
| SCHEMBL14549781 | 0.79 | GUCY1A1 (1.00) | GUCY1A1GUCY1B1KCNH2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549875-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | claimed |
| WO-2011119518-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2011-09-29 | — | — | WO | claimed |