SCHEMBL2554923

SCHEMBL2554923

O=Cc1cccc(OCC(=O)Nc2cccc(Cl)c2)c1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 2/20 0.60
LMNA P02545 3/20 0.58
ALDH1A1 P00352 1/20 0.58
HDAC4 P56524 1/20 0.54
TP53 P04637 2/20 0.54
GAA P10253 1/20 0.54
ALOX12 P18054 1/20 0.54
MAPT P10636 3/20 0.53
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
NPC1 O15118 2/20 0.53
RAB9A P51151 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
THRB P10828 1/20 0.52
RXFP1 Q9HBX9 1/20 0.52
MAOA P21397 1/20 0.52
MAOB P27338 1/20 0.52
HPGD P15428 1/20 0.51
MAPK1 P28482 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2564545 0.89 MAPT (0.62) NOTUMLMNAALDH1A1HDAC4TP53
SCHEMBL2561801 0.89 KMT2A (0.56) NOTUMLMNAALDH1A1GAAMAPT
SCHEMBL15330595 0.87 NPC1 (0.65) NOTUMLMNAALDH1A1TP53MAPT
SCHEMBL2561781 0.85 MAPK1 (0.72) NOTUMLMNAALDH1A1TP53MEN1
SCHEMBL2553661 0.85 NPC1 (0.72) ALDH1A1TP53MAPTMEN1KMT2A
SCHEMBL23419659 0.84 NPC1 (0.67) NOTUMLMNAALDH1A1TP53MAPT
SCHEMBL2561612 0.81 NPC1 (0.61) ALDH1A1GAAMAPTMEN1KMT2A
SCHEMBL2559333 0.81 HTT (0.60) LMNAALDH1A1TP53MAPTMEN1
SCHEMBL2561447 0.81 SMN1; SMN2 (0.67) ALDH1A1HDAC4MAPTMEN1KMT2A
SCHEMBL2559946 0.81 MAPK1 (0.59) NOTUMLMNAALDH1A1TP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed