Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 15/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | NEK2 | P51955 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21446892 | 0.90 | AXL (0.80) | AXLAURKBAURKAPTK2ALK | |
| SCHEMBL25550379 | 0.90 | AXL (0.67) | AXLAURKBAURKAPTK2ALK | |
| SCHEMBL13644148 | 0.88 | AXL (0.84) | AXLAURKBAURKAPTK2ALK | |
| SCHEMBL21446889 | 0.81 | AXL (0.66) | AXLAURKBAURKAPTK2ALK | |
| SCHEMBL25549741 | 0.79 | AXL (0.84) | AXLAURKBAURKAPTK2ALK | |
| Dubermatinib SCHEMBL12813478 | 0.79 | AXL (1.00) | AXLAURKBAURKAPTK2ALK | |
| SCHEMBL12964722 | 0.79 | AXL (1.00) | AXLAURKBAURKAPTK2ALK | |
| Dubermatinib SCHEMBL29394359 | 0.79 | AXL (1.00) | AXLAURKBAURKAPTK2ALK | |
| SCHEMBL25838418 | 0.79 | AXL (0.66) | AXLAURKBAURKAPTK2ALK | |
| SCHEMBL22872031 | 0.79 | AXL (0.63) | AXLAURKBAURKAPTK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230165857-A1 | AXL KINASE INHIBITORS AND USE OF THE SAME | SUMITOMO PHARMA ONCOLOGY, INC. | 2023-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230165857-A1 | AXL KINASE INHIBITORS AND USE OF THE SAME | AXL, FLT3, TEC | AXL 1/4885AURKB 164/4885AURKA 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.