SCHEMBL2556124

SCHEMBL2556124

O=Cc1sc(Oc2ccc(F)c(F)c2)nc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.44
MEN1 O00255 5/20 0.44
MAPT P10636 5/20 0.44
ALDH1A1 P00352 2/20 0.40
POLB P06746 2/20 0.40
KDM4E B2RXH2 1/20 0.40
LMNA P02545 4/20 0.40
PSMD14 O00487 1/20 0.40
GLA P06280 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
SOS1 Q07889 2/20 0.36
CASP6 P55212 1/20 0.35
CNR1 P21554 3/20 0.33
CNR2 P34972 3/20 0.33
MAP4K4 O95819 1/20 0.33
SCN9A Q15858 3/20 0.32
HPGD P15428 1/20 0.32
TRPA1 O75762 1/20 0.32
LTA4H P09960 1/20 0.31
EPHX2 P34913 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2559484 0.84 MAPT (0.47) KMT2AMEN1MAPTALDH1A1POLB
SCHEMBL2563053 0.84 MEN1 (0.49) KMT2AMEN1MAPTALDH1A1POLB
SCHEMBL3744273 0.83 SOS1 (0.36) KMT2AMEN1MAPTALDH1A1POLB
SCHEMBL2555365 0.83 MEN1 (0.46) KMT2AMEN1MAPTALDH1A1POLB
SCHEMBL2561182 0.82 MAPT (0.42) KMT2AMEN1MAPTALDH1A1POLB
SCHEMBL2559272 0.82 MEN1 (0.43) KMT2AMEN1MAPTALDH1A1POLB
SCHEMBL2558710 0.81 MAPT (0.49) KMT2AMEN1MAPTALDH1A1POLB
SCHEMBL2553580 0.78 MEN1 (0.54) KMT2AMEN1MAPTALDH1A1POLB
SCHEMBL2554863 0.78 MAPT (0.57) KMT2AMEN1MAPTALDH1A1POLB
SCHEMBL2561164 0.78 MAPT (0.64) KMT2AMEN1MAPTALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed