⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4425211 | 0.75 | — | — | |
| SCHEMBL28944916 | 0.71 | — | — | |
| SCHEMBL14993152 | 0.71 | — | — | |
| SCHEMBL27691179 | 0.71 | — | — | |
| SCHEMBL6559750 | 0.71 | — | — | |
| SCHEMBL1414891 | 0.71 | — | — | |
| SCHEMBL647294 | 0.71 | — | — | |
| SCHEMBL2658924 | 0.71 | — | — | |
| SCHEMBL680097 | 0.71 | — | — | |
| SCHEMBL236174 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708679-B1 | PHARMACEUTICAL SPRAY FORMULATION COMPRISING A HYDRO FLUOR ALKANE AND AN ACYLATED CYCLODEXTRIN | ASTRAZENECA AB (SE) | 2008-11-12 | — | — | EP | claimed |
| US-20080124757-A1 | DISCRETE ACYLTRANSFERASES ASSOCIATED WITH TYPE I POLYKETIDE SYNTHASES AND METHODS OF USE | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-05-29 | — | — | US | claimed |
| CN-101087600-A | Pharmaceutical spray formulation comprising a hydro fluor alkane and an acylated cyclodextrin | ASTRAZENECA AB (SE) | 2007-12-12 | — | — | CN | claimed |
| US-20070104652-A1 | Pharmaceutical spray formulation comprising a hydro fluor alkane and an acylated cyclodextrin | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | US | claimed |
| EP-1708679-A2 | PHARMACEUTICAL SPRAY FORMULATION COMPRISING A HYDRO FLUOR ALKANE AND AN ACYLATED CYCLODEXTRIN | AstraZeneca AB (SE) | 2006-10-11 | — | — | EP | claimed |
| WO-2005053637-A2 | PHARMACEUTICAL SPRAY FORMULATION COMPRISING A HYPRO FLUOR ALKANE AMD AN ACYLATED CYCLODEXTRIN | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | WO | claimed |
| US-20030175888-A1 | Discrete acyltransferases associated with type I polyketide synthases and methods of use | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2003-09-18 | — | — | US | claimed |
| CN-110643652-B | Method for synthesizing quinolizinone compound by enzyme method | 北京中医药大学 | 2021-05-11 | — | — | CN | disclosed |
| CN-111334500-A | Method for preparing streptomyces strain with high tacrolimus yield by mutagenesis | 浙江弘盛药业有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-111334500-A | Method for preparing streptomyces strain with high tacrolimus yield by mutagenesis | 浙江弘盛药业有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-110643652-A | Method for synthesizing quinolizinone compound by enzyme method | 北京中医药大学 | 2020-01-03 | — | — | CN | disclosed |
| CN-110251511-A | The FK506 derivative and application thereof of the maintenance neuroregenerative activity of no immunosuppressive activity | 尹特荣生物科技株式会社 | 2019-09-20 | — | — | CN | disclosed |
| CN-107683286-A | Plasmepsin V structure compound with inhibitor and application thereof | 沃尔特及伊莱萨霍尔医学研究院 | 2018-02-09 | — | — | CN | disclosed |
| US-20020111317-A1 | Sixteen-membered macrolide compounds | KOSAN BIOSCIENCES, INC. | 2002-08-15 | — | — | US | disclosed |
| WO-2002032916-A2 | SIXTEEN-MEMBERED MACROLIDE COMPOUNDS | KOSAN BIOSCIENCES, INC. (US) | 2002-04-25 | — | — | WO | disclosed |
| CN-1333820-A | Recombinant methods and materials for producing epothilone and eopthilone derivatives | KOSAN BIOSCIENCES INC (US) | 2002-01-30 | — | — | CN | disclosed |
| US-6303342-B1 | CULTURING CELL THAT CONTAINS NUCLEIC ACID CODING FOR EXPRESSION OF SORANGIUM CELLULOSUM EPOTHILONE POLYKETIDE SYNTHASE; ANTICARCINOGENIC AGENTS, FUNGICIDES, IMMUNOSUPPRESSANTS | KASON BIOSCIENCES, INC. | 2001-10-16 | — | — | US | disclosed |
| EP-0463707-A1 | Production of polyketide antibiotics | LUBRIZOL GENETICS INC. (US) | 1992-01-02 | — | — | EP | disclosed |
| EP-0262154-A1 | ISOLATION OF GENES FOR BIOSYNTHESIS OF POLYKETIDE ANTIBIOTICS | LUBRIZOL GENETICS INC. (US) | 1988-04-06 | — | — | EP | disclosed |
| WO-1987003907-A1 | ISOLATION OF GENES FOR BIOSYNTHESIS OF POLYKETIDE ANTIBIOTICS | LUBRIZOL GENETICS, INC. (US) | 1987-07-02 | — | — | WO | disclosed |