Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25571582 | 0.86 | NPC1 (0.64) | NPC1CARM1PRMT6PRMT8SIGMAR1 | |
| SCHEMBL25621681 | 0.85 | NPC1 (0.53) | NPC1CARM1PRMT6PRMT8SIGMAR1 | |
| SCHEMBL27097601 | 0.83 | NPC1 (0.50) | NPC1CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL13367 | 0.83 | NPC1 (0.66) | NPC1CYP1A2HRH3 | |
| SCHEMBL26949128 | 0.83 | NPC1 (0.47) | NPC1CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL27271088 | 0.80 | NPC1 (0.45) | NPC1CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL18713115 | 0.80 | NPC1 (0.67) | NPC1KDM4EHRH3KMT2AALDH1A1 | |
| SCHEMBL13086520 | 0.80 | NPC1 (0.52) | NPC1SIGMAR1KDM4ECYP1A2TDP1 | |
| SCHEMBL12829 | 0.80 | KDM4E (0.49) | NPC1KDM4ETDP1HRH3LMNA | |
| SCHEMBL12449678 | 0.80 | KDM4E (0.49) | NPC1KDM4ETDP1HRH3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023083194-A1 | WEE1 PROTEIN KINASE DEGRADATION AGENT AND USE THEREOF | 杭州格博生物医药有限公司 | 2023-05-19 | — | — | WO | disclosed |