Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 18/20 | 0.41 |
| ▸ | HTR2B | P41595 | 16/20 | 0.41 |
| ▸ | HTR2A | P28223 | 13/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017396 | 1.00 | HTR2C (0.41) | HTR2CHTR2BHTR2AHTR6BRD4 | |
| SCHEMBL2015846 | 0.88 | CREBBP (0.40) | HTR2CHTR2BHTR2AHTR6BRD4 | |
| SCHEMBL2019627 | 0.88 | CREBBP (0.40) | HTR2CHTR2BHTR2AHTR6BRD4 | |
| SCHEMBL692525 | 0.88 | CREBBP (0.40) | HTR2CHTR2BHTR2AHTR6BRD4 | |
| SCHEMBL2016837 | 0.88 | CREBBP (0.40) | HTR2CHTR2BHTR2AHTR6BRD4 | |
| SCHEMBL692948 | 0.88 | BRD4 (0.42) | HTR2CHTR2BHTR2AHTR6BRD4 | |
| SCHEMBL2018403 | 0.88 | CREBBP (0.40) | HTR2CHTR2BHTR2AHTR6BRD4 | |
| SCHEMBL2017687 | 0.88 | CREBBP (0.40) | HTR2CHTR2BHTR2AHTR6BRD4 | |
| SCHEMBL2019541 | 0.85 | HTR2C (0.42) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL691343 | 0.85 | HTR2C (0.47) | HTR2CHTR2BHTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | claimed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | claimed |
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | disclosed |