SCHEMBL25566827

SCHEMBL25566827

Cn1nc([C@@H]2CCC(=O)NC2=O)c2cc(F)cc(C(C)(C)C)c21

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 20/20 0.54
CRBN Q96SW2 20/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25594936 1.00 DDB1 (0.54) DDB1CRBN
SCHEMBL25857312 0.85 DDB1 (0.57) DDB1CRBN
SCHEMBL25566828 0.83 DDB1 (0.54) DDB1CRBN
SCHEMBL25566694 0.83 DDB1 (0.54) DDB1CRBN
SCHEMBL24132057 0.82 DDB1 (0.72) DDB1CRBN
SCHEMBL25566697 0.78 DDB1 (0.52) DDB1CRBN
SCHEMBL25566693 0.78 CRBN (0.60) DDB1CRBN
SCHEMBL25567336 0.74 DDB1 (0.64) DDB1CRBN
SCHEMBL25956098 0.74 DDB1 (0.47) DDB1CRBN
SCHEMBL30735101 0.73 DDB1 (0.72) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023083194-A1 WEE1 PROTEIN KINASE DEGRADATION AGENT AND USE THEREOF 杭州格博生物医药有限公司 2023-05-19 WO disclosed