Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173479 | 0.76 | MAP2K1 (0.31) | MAP2K1 | |
| SCHEMBL1392718 | 0.75 | CCNA2 (0.44) | CCNA2CDK2CCNA1 | |
| SCHEMBL1393057 | 0.73 | AURKA (0.45) | CCNA2CDK2CCNA1NPC1RAB9A | |
| SCHEMBL16650852 | 0.71 | BRD4 (0.44) | MAPTLMNAKDM4ESMN1; SMN2POLB | |
| SCHEMBL1038553 | 0.70 | IGF1R (0.38) | — | |
| SCHEMBL1394172 | 0.70 | TNIK (0.32) | MAP2K1 | |
| SCHEMBL13139728 | 0.69 | KDM1A (0.32) | MAPTLMNA | |
| SCHEMBL14914695 | 0.68 | BTK (0.34) | — | |
| SCHEMBL14925807 | 0.68 | CCNA2 (0.44) | CCNA2CDK2CCNA1 | |
| SCHEMBL10289556 | 0.68 | IDO1 (0.40) | MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012031004-A1 | PYRIDINONES/PYRAZINONES, METHOD OF MAKING, AND METHOD OF USE THEREOF | GILEAD CONNECTICUT, INC. (US) | 2012-03-08 | — | — | WO | disclosed |