Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.86 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.86 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.86 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.86 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.86 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.86 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.86 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.86 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.86 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.86 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.86 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.86 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.86 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.86 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.86 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.86 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.86 |
| ▸ | MTOR | P42345 | 2/20 | 0.86 |
| ▸ | PRKDC | P78527 | 1/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fimepinostat SCHEMBL29493089 | 0.93 | HDAC1 (1.00) | HDAC1HDAC2HDAC10HDAC11HDAC6 | |
| Fimepinostat SCHEMBL1284705 | 0.93 | HDAC1 (1.00) | HDAC1HDAC2HDAC10HDAC11HDAC6 | |
| Fimepinostat SCHEMBL29353052 | 0.93 | HDAC1 (1.00) | HDAC1HDAC2HDAC10HDAC11HDAC6 | |
| Fimepinostat SCHEMBL12813120 | 0.92 | HDAC1 (0.99) | HDAC1HDAC2HDAC10HDAC11HDAC6 | |
| Fimepinostat SCHEMBL12813122 | 0.92 | HDAC1 (0.99) | HDAC1HDAC2HDAC10HDAC11HDAC6 | |
| Fimepinostat SCHEMBL12813054 | 0.92 | HDAC1 (0.99) | HDAC1HDAC2HDAC10HDAC11HDAC6 | |
| Fimepinostat SCHEMBL29666301 | 0.92 | HDAC1 (0.99) | HDAC1HDAC2HDAC10HDAC11HDAC6 | |
| Fimepinostat SCHEMBL12813051 | 0.92 | HDAC1 (0.99) | HDAC1HDAC2HDAC10HDAC11HDAC6 | |
| Fimepinostat SCHEMBL29666166 | 0.92 | HDAC1 (0.99) | HDAC1HDAC2HDAC10HDAC11HDAC6 | |
| SCHEMBL2559157 | 0.91 | HDAC1 (0.71) | HDAC1HDAC2HDAC10HDAC11HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2557923-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | Curis, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011130628-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |