SCHEMBL2558795

SCHEMBL2558795

NC(=O)c1ccccc1N1CCC(C(=O)O)CC1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.64
NOTUM Q6P988 6/20 0.55
RAB9A P51151 1/20 0.50
MAPT P10636 2/20 0.49
POLB P06746 2/20 0.49
APAF1 O14727 1/20 0.49
NSD2 O96028 1/20 0.49
THRB P10828 1/20 0.49
CASP3 P42574 1/20 0.49
RECQL P46063 1/20 0.49
GALK1 P51570 1/20 0.49
KMT2A Q03164 1/20 0.49
HKDC1 Q2TB90 1/20 0.49
SENP8 Q96LD8 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
SENP6 Q9GZR1 1/20 0.49
SAE1 Q9UBE0 1/20 0.49
UBA2 Q9UBT2 1/20 0.49
KDM4E B2RXH2 1/20 0.47
CYP2C19 P33261 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15330260 0.91 NOTUM (0.68) NPC1NOTUM
SCHEMBL3084334 0.84 NPC1 (0.68) NPC1NOTUMMAPTTHRBKMT2A
SCHEMBL2260505 0.84 NPC1 (0.68) NPC1NOTUMMAPTTHRBKMT2A
SCHEMBL29752319 0.83 NPC1 (0.66) NPC1RAB9AMAPTPOLBKMT2A
SCHEMBL3088803 0.83 NPC1 (0.66) NPC1RAB9AMAPTPOLBKMT2A
SCHEMBL2558871 0.82 NPC1 (0.61) NPC1NOTUMKMT2AKDM4EGAA
SCHEMBL2559578 0.81 KMT2A (0.60) NOTUMRAB9AMAPTPOLBAPAF1
SCHEMBL5800932 0.80 NOTUM (0.81) NOTUMRAB9AMAPTPOLBAPAF1
SCHEMBL3096106 0.80 NPC1 (0.62) NPC1MAPTTHRBKMT2AKDM4E
SCHEMBL3654065 0.80 NPC1 (0.96) NPC1MAPTTHRBKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed