Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.53 |
| ▸ | CTSD | P07339 | 14/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4213432 | 0.93 | BACE1 (0.52) | BACE1CTSDBACE2 | |
| SCHEMBL4215387 | 0.93 | BACE1 (0.52) | BACE1CTSDBACE2 | |
| SCHEMBL4218395 | 0.93 | BACE1 (0.55) | BACE1CTSDBACE2 | |
| SCHEMBL4220620 | 0.92 | BACE1 (0.59) | BACE1CTSDBACE2 | |
| SCHEMBL168969 | 0.92 | BACE1 (0.59) | BACE1CTSDBACE2 | |
| SCHEMBL4212486 | 0.92 | BACE1 (0.55) | BACE1CTSDBACE2 | |
| SCHEMBL4216356 | 0.92 | BACE1 (0.55) | BACE1CTSDBACE2 | |
| SCHEMBL3510028 | 0.92 | BACE1 (0.53) | BACE1CTSDBACE2 | |
| SCHEMBL4216833 | 0.91 | BACE1 (0.52) | BACE1CTSDBACE2 | |
| SCHEMBL4211738 | 0.91 | BACE1 (0.52) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028563-A1 | BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-08 | — | — | WO | disclosed |