Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25589205 | 0.92 | FGFR1 (0.41) | FGFR1FGFR2FGFR4FGFR3ERBB2 | |
| SCHEMBL25589185 | 0.92 | FGFR4 (0.44) | FGFR1FGFR2FGFR4FGFR3ERBB2 | |
| SCHEMBL25589206 | 0.91 | BTK (0.44) | FGFR1FGFR2FGFR4FGFR3TGM2 | |
| SCHEMBL25589193 | 0.91 | FGFR4 (0.39) | FGFR1FGFR2FGFR4FGFR3ERBB2 | |
| SCHEMBL25589190 | 0.90 | FGFR1 (0.42) | FGFR1FGFR2FGFR4FGFR3ERBB2 | |
| SCHEMBL24992106 | 0.89 | FGFR1 (0.47) | FGFR1FGFR2FGFR4FGFR3ERBB2 | |
| SCHEMBL25589203 | 0.89 | FGFR1 (0.39) | FGFR1FGFR2FGFR4FGFR3ERBB2 | |
| SCHEMBL25600094 | 0.89 | FGFR1 (0.45) | FGFR1FGFR2FGFR4FGFR3TGM2 | |
| SCHEMBL25597080 | 0.89 | FGFR1 (0.42) | FGFR1FGFR2FGFR4FGFR3ERBB2 | |
| SCHEMBL25589194 | 0.89 | FGFR1 (0.40) | FGFR1FGFR2FGFR4FGFR3ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078413-A1 | FGFR2 INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 微境生物医药科技(上海)有限公司 | 2023-05-11 | — | — | WO | disclosed |