Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 19/20 | 0.57 |
| ▸ | CDK12 | Q9NYV4 | 18/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 17/20 | 0.57 |
| ▸ | CDK9 | P50750 | 17/20 | 0.57 |
| ▸ | CDK2 | P24941 | 16/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.57 |
| ▸ | CDK7 | P50613 | 7/20 | 0.55 |
| ▸ | CCNH | P51946 | 7/20 | 0.55 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27120599 | 1.00 | CCNK (0.57) | CCNKCDK12CCNT1CDK9CDK2 | |
| SCHEMBL25594125 | 0.93 | CCNK (0.66) | CCNKCDK12CCNT1CDK9CDK2 | |
| SCHEMBL26967511 | 0.91 | CCNK (0.69) | CCNKCDK12CCNT1CDK9CDK2 | |
| SCHEMBL25593958 | 0.91 | CCNK (0.69) | CCNKCDK12CCNT1CDK9CDK2 | |
| SCHEMBL25593753 | 0.89 | CCNK (0.57) | CCNKCDK12CCNT1CDK9CDK2 | |
| SCHEMBL25582183 | 0.88 | CCNK (0.54) | CCNKCDK12CCNT1CDK9CDK2 | |
| SCHEMBL25593261 | 0.88 | CCNK (0.63) | CCNKCDK12CCNT1CDK9CDK2 | |
| SCHEMBL29492509 | 0.88 | CCNK (0.63) | CCNKCDK12CCNT1CDK9CDK2 | |
| SCHEMBL27121866 | 0.88 | CCNK (0.63) | CCNKCDK12CCNT1CDK9CDK2 | |
| SCHEMBL24588967 | 0.86 | CCNK (0.67) | CCNKCDK12CCNT1CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4295852-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |