Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CDK7 | P50613 | 3/20 | 0.40 |
| ▸ | CCNH | P51946 | 3/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25681606 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9AGLANPC1KDM4E | |
| SCHEMBL25599129 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9AGLANPC1KDM4E | |
| SCHEMBL25598176 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AGLANPC1KDM4E | |
| SCHEMBL25599144 | 0.83 | MAPT (0.45) | SMN1; SMN2RAB9AGLANPC1KDM4E | |
| SCHEMBL25599169 | 0.83 | CTSC (0.47) | RAB9ACCNKCCNA2CDK2CDK7 | |
| SCHEMBL25682250 | 0.83 | CTSC (0.47) | RAB9ACCNKCCNA2CDK2CDK7 | |
| SCHEMBL25681648 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9AGLANPC1KDM4E | |
| SCHEMBL25268057 | 0.79 | CCNK (0.50) | CCNKCCNA2CDK2CDK7CCNH | |
| SCHEMBL25217630 | 0.79 | CCNK (0.50) | CCNKCCNA2CDK2CDK7CCNH | |
| SCHEMBL25273469 | 0.79 | CCNK (0.57) | CCNKCCNA2CDK2CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |