Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | TYMP | P19971 | 5/20 | 0.33 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23540965 | 0.83 | AR (0.41) | IDH1CSNK2A2CSNK2BCSNK2A1TYMP | |
| SCHEMBL29947950 | 0.83 | AR (0.41) | IDH1CSNK2A2CSNK2BCSNK2A1TYMP | |
| SCHEMBL30168669 | 0.81 | IDH1 (0.36) | IDH1CSNK2A2CSNK2BCSNK2A1TYMP | |
| SCHEMBL29388927 | 0.81 | IDH1 (0.36) | IDH1CSNK2A2CSNK2BCSNK2A1TYMP | |
| SCHEMBL24791176 | 0.81 | GRIN2D (0.38) | IDH1CSNK2A2CSNK2BCSNK2A1TYMP | |
| SCHEMBL23539934 | 0.81 | IDH1 (0.36) | IDH1CSNK2A2CSNK2BCSNK2A1TYMP | |
| SCHEMBL16637455 | 0.81 | IDH1 (0.36) | IDH1CSNK2A2CSNK2BCSNK2A1TYMP | |
| SCHEMBL7026627 | 0.75 | IDH1 (0.35) | IDH1CSNK2A2CSNK2BCSNK2A1TYMP | |
| SCHEMBL7034331 | 0.74 | GRIN2D (0.50) | TYMPDAOGDAKDM4ECA12 | |
| SCHEMBL24790701 | 0.72 | KDM4E (0.39) | TYMPKDM4EALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023097195-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |