Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2556467 | 0.91 | PDE10A (0.63) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2557873 | 0.90 | PDE10A (0.69) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7707777 | 0.90 | PDE10A (0.75) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2560037 | 0.88 | PDE10A (0.58) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2563116 | 0.86 | PDE10A (0.59) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2563558 | 0.84 | PDE10A (0.55) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2560629 | 0.84 | PDE10A (0.84) | PDE10APDE4B | |
| SCHEMBL2565185 | 0.83 | PDE10A (0.53) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2576417 | 0.83 | PDE10A (0.62) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7712120 | 0.82 | PDE10A (0.61) | PDE10APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | claimed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |