SCHEMBL25602149

SCHEMBL25602149

CC1(C)c2cc(C#N)ccc2-c2c1c1c(c3ccccc23)OC(c2ccc(N3CCCCC3)cc2)(c2ccc3c(c2)C(c2ccccc2)(c2ccccc2)c2ccccc2-3)C=C1

nearest known ligand 0.37

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 13/20 0.37
KIT P10721 2/20 0.32
KDR P35968 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25602264 0.95 ALK (0.40) ALKKITKDR
SCHEMBL25714460 0.94 ALK (0.39) ALKKITKDR
SCHEMBL25604193 0.92 PDK2 (0.31)
SCHEMBL25602410 0.91 ALK (0.43) ALKKITKDR
SCHEMBL25844112 0.90
SCHEMBL25602146 0.89 ALK (0.38) ALKKITKDR
SCHEMBL25602148 0.89 ALK (0.38) ALKKITKDR
SCHEMBL25602251 0.89 ALK (0.42) ALKKITKDR
SCHEMBL25602145 0.88 ALK (0.40) ALKKITKDR
SCHEMBL25602404 0.88 ALK (0.45) ALKKITKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed
EP-4198102-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES Hoya Lens Thailand Ltd. (TH) 2023-06-21 EP disclosed
EP-4198583-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES Hoya Lens Thailand Ltd. (TH) 2023-06-21 EP disclosed