Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19477142 | 1.00 | IGF1R (0.48) | IGF1RAURKAAURKBCDK2MAPK1 | |
| SCHEMBL19477149 | 1.00 | IGF1R (0.48) | IGF1RAURKAAURKBCDK2MAPK1 | |
| SCHEMBL19477147 | 0.90 | IGF1R (0.48) | IGF1RAURKAAURKBCDK2MAPK1 | |
| SCHEMBL19476818 | 0.88 | AURKA (0.49) | IGF1RAURKAAURKBCDK2MAPK1 | |
| SCHEMBL19476830 | 0.88 | AURKA (0.49) | IGF1RAURKAAURKBCDK2MAPK1 | |
| SCHEMBL19700678 | 0.88 | AURKA (0.49) | IGF1RAURKAAURKBCDK2MAPK1 | |
| SCHEMBL25610360 | 0.84 | EHMT2 (0.54) | IGF1RAURKAAURKBCDK2MAPK1 | |
| SCHEMBL19477148 | 0.84 | EHMT2 (0.54) | IGF1RAURKAAURKBCDK2MAPK1 | |
| SCHEMBL19477145 | 0.84 | EHMT2 (0.54) | IGF1RAURKAAURKBCDK2MAPK1 | |
| SCHEMBL19477144 | 0.81 | EHMT2 (0.53) | IGF1RAURKAAURKBCDK2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442947-B1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | EPIZYME INC (US) | 2023-06-07 | — | — | EP | disclosed |