Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.72 |
| ▸ | GSK3B | P49841 | 9/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.55 |
| ▸ | WNT1 | P04628 | 4/20 | 0.55 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25606129 | 0.88 | MKNK1 (0.77) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25219590 | 0.87 | MKNK1 (0.76) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25609256 | 0.81 | MKNK1 (0.81) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25605170 | 0.80 | MKNK1 (0.74) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25611765 | 0.77 | DYRK1A (0.74) | MKNK1GSK3BDYRK1AWNT1 | |
| SCHEMBL25610896 | 0.75 | MKNK1 (0.61) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25602720 | 0.75 | DYRK1A (0.77) | MKNK1GSK3BDYRK1AWNT1 | |
| SCHEMBL31501400 | 0.75 | DYRK1A (0.77) | MKNK1GSK3BDYRK1AWNT1 | |
| SCHEMBL25602732 | 0.75 | MKNK1 (0.69) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL31501339 | 0.75 | MKNK1 (0.60) | MKNK1GSK3BDYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107714-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |