Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27629274 | 0.84 | SLC6A4 (0.60) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5000089 | 0.82 | SLC6A4 (0.65) | SLC6A2SLC6A4HTR1AHTR1DCACNA2D1 | |
| SCHEMBL3458 | 0.79 | SLC6A2 (0.71) | SLC6A2SLC6A4HTR1AHTR1DCACNA2D1 | |
| SCHEMBL3967638 | 0.79 | SLC6A4 (1.00) | SLC6A2SLC6A4HTR1ACACNA2D1SLC6A3 | |
| SCHEMBL3359634 | 0.79 | SLC6A4 (1.00) | SLC6A2SLC6A4HTR1ACACNA2D1SLC6A3 | |
| SCHEMBL1535357 | 0.79 | SLC6A2 (0.69) | SLC6A2SLC6A4HTR1ACACNA2D1SLC6A3 | |
| Hydrochloric Acid SCHEMBL4413256 | 0.78 | SLC6A4 (0.98) | SLC6A2SLC6A4HTR1ACACNA2D1SLC6A3 | |
| SCHEMBL3563 | 0.78 | SLC6A2 (0.56) | SLC6A2SLC6A4HTR1AHTR1DCACNA2D1 | |
| SCHEMBL3449 | 0.78 | SLC6A2 (0.62) | SLC6A2SLC6A4HTR1AHTR1DCACNA2D1 | |
| Hydrochloric Acid SCHEMBL4743162 | 0.78 | SLC6A2 (0.67) | SLC6A2SLC6A4HTR1ACACNA2D1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558455-A1 | SYNTHESIS OF DULOXETINE AND/OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | KRKA, D.D., Novo Mesto (SI) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011128370-A1 | SYNTHESIS OF DULOXETINE AND/OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | KRKA, D.D., NOVO MESTO (SI) | 2011-10-20 | — | — | WO | disclosed |