Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.51 |
| ▸ | JAK1 | P23458 | 6/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2569096 | 0.78 | TTK (0.60) | HPGDNPC1RAB9AKMT2A | |
| SCHEMBL14863599 | 0.77 | JAK2 (0.51) | JAK2JAK1ULK1ITKAURKA | |
| SCHEMBL2565163 | 0.77 | JAK2 (0.56) | JAK2JAK1KCNK3ULK1HPGD | |
| SCHEMBL2380312 | 0.77 | CDK7 (0.45) | JAK2JAK1KCNK3KCNK9HPGD | |
| SCHEMBL2564735 | 0.76 | ITK (0.55) | JAK2JAK1HPGDKMT2AITK | |
| SCHEMBL2582272 | 0.75 | TTK (0.72) | AURKA | |
| SCHEMBL2564063 | 0.75 | NPC1 (0.68) | JAK2NPC1RAB9AKMT2A | |
| SCHEMBL2555715 | 0.74 | TTK (0.67) | ULK1LRRK2KMT2AAURKA | |
| SCHEMBL14863628 | 0.74 | TTK (0.64) | ULK1LRRK2KMT2AAURKA | |
| SCHEMBL14863466 | 0.73 | TTK (0.66) | ULK1LRRK2KMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |