Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 8/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560575 | 0.89 | PDE4B (0.46) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2560888 | 0.88 | PDE10A (0.48) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2563217 | 0.88 | PDE10A (0.49) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2577646 | 0.88 | PDE10A (0.47) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2556896 | 0.88 | PDE10A (0.49) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2558454 | 0.87 | PDE4B (0.49) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2560140 | 0.87 | PDE10A (0.47) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2563041 | 0.86 | PDE10A (0.47) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2576250 | 0.85 | PDE10A (0.46) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2557534 | 0.85 | PDE10A (0.47) | PDE4APDE4BPDE4DPDE4CPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | claimed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |