Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.88 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.88 |
| ▸ | PLK2 | Q9NYY3 | 8/20 | 0.88 |
| ▸ | FLT3 | P36888 | 5/20 | 0.86 |
| ▸ | NEK6 | Q9HC98 | 3/20 | 0.86 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.82 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.82 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.82 |
| ▸ | MELK | Q14680 | 1/20 | 0.82 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.82 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.78 |
| ▸ | CDK2 | P24941 | 4/20 | 0.78 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.78 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503601 | 0.94 | PLK1 (1.00) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL3503253 | 0.93 | PLK1 (1.00) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25626294 | 0.92 | PLK1 (0.77) | PLK1PLK3PLK2FLT3NEK6 | |
| Onvansertib SCHEMBL29379736 | 0.90 | PLK1 (1.00) | PLK1PLK3PLK2FLT3NEK6 | |
| Onvansertib SCHEMBL1228019 | 0.90 | PLK1 (1.00) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25623951 | 0.90 | PLK1 (0.83) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL3503624 | 0.89 | PLK1 (1.00) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL15377692 | 0.89 | PLK1 (0.91) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL3504626 | 0.88 | PLK1 (1.00) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL3502388 | 0.88 | PLK1 (1.00) | PLK1PLK3PLK2FLT3NEK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104178-A1 | PROTEIN KINASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 山东绿叶制药有限公司 | 2023-06-15 | — | — | WO | disclosed |