Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.73 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3181783 | 0.84 | APP (1.00) | APPNPC1RAB9AMEN1KMT2A | |
| SCHEMBL3190436 | 0.82 | APP (0.70) | APPNPC1RAB9AMEN1KMT2A | |
| SCHEMBL27188287 | 0.82 | APP (0.49) | APPNPC1RAB9AMEN1KMT2A | |
| SCHEMBL25624847 | 0.80 | NPC1 (0.53) | APPNPC1RAB9AMEN1KMT2A | |
| SCHEMBL25624863 | 0.79 | APP (0.65) | APPNPC1RAB9AMEN1KMT2A | |
| SCHEMBL10173054 | 0.78 | HDAC6 (0.64) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL3181272 | 0.76 | APP (0.84) | APPNPC1RAB9AESR1ESR2 | |
| SCHEMBL2245900 | 0.76 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL17929625 | 0.75 | APP (0.59) | APPNPC1RAB9AMEN1KMT2A | |
| SCHEMBL17929628 | 0.75 | APP (0.59) | APPNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109745-A1 | SMALL-MOLECULE PROBE FOR IMAGING OF α-SYNUCLEIN AGGREGATE | 复旦大学 | 2023-06-22 | — | — | WO | disclosed |