Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.50 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.50 |
| ▸ | FLT3 | P36888 | 4/20 | 0.50 |
| ▸ | NEK6 | Q9HC98 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | MELK | Q14680 | 1/20 | 0.48 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25626516 | 0.90 | PLK1 (0.57) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25623968 | 0.90 | PLK1 (0.59) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25624722 | 0.88 | PLK1 (0.58) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25626388 | 0.88 | PLK1 (0.45) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25627196 | 0.87 | PLK1 (0.60) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25626755 | 0.86 | PLK1 (0.60) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25624130 | 0.86 | PLK1 (0.59) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25627070 | 0.86 | PLK1 (0.55) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25624679 | 0.86 | PLK1 (0.59) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL25626949 | 0.85 | PLK1 (0.51) | PLK1PLK3PLK2FLT3NEK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104178-A1 | PROTEIN KINASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 山东绿叶制药有限公司 | 2023-06-15 | — | — | WO | disclosed |