Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.52 |
| ▸ | FEN1 | P39748 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402781 | 0.83 | GSK3B (0.55) | GSK3BERCC5FEN1MAPTL3MBTL1 | |
| SCHEMBL3415923 | 0.81 | GSK3B (0.57) | GSK3BERCC5FEN1MAPTL3MBTL1 | |
| SCHEMBL4966553 | 0.80 | NPC1 (0.56) | MAPTL3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL6832412 | 0.80 | TSHR (0.55) | CES2CES1ALOX15TSHRALDH1A1 | |
| Ethylene SCHEMBL11680949 | 0.80 | GSK3B (0.40) | GSK3BMAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL9110541 | 0.79 | GSK3B (0.55) | GSK3BERCC5FEN1MAPTL3MBTL1 | |
| SCHEMBL7789029 | 0.79 | GSK3B (0.55) | GSK3BERCC5FEN1MAPTL3MBTL1 | |
| SCHEMBL8975154 | 0.78 | HDAC1 (0.61) | GSK3BMAPTL3MBTL1CES2CES1 | |
| SCHEMBL2561194 | 0.78 | NPC1 (0.57) | MAPTCES2CES1NPC1RAB9A | |
| SCHEMBL29242031 | 0.78 | TPMT (0.48) | GSK3BMAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111961004-B | Method for preparing medical intermediate 2, 4, 6-triaryl pyrimidine derivative through catalysis | 马鞍山市泰博化工科技有限公司 | 2021-11-12 | — | — | CN | claimed |
| CN-119409676-A | Preparation method for synthesizing chiral beta-hydroxy propanal ethylene glycol with high enantioselectivity | 贵州金之键高科技材料股份有限公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-117466817-A | Preparation method of polysubstituted pyrazole derivative | 华侨大学 | 2024-01-30 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| CN-110143935-B | Preparation method of 2, 5-disubstituted furan derivative | 华侨大学 | 2022-09-30 | — | — | CN | disclosed |
| US-11225655-B2 | Bi-functional complexes and methods for making and using such complexes | NUEVOLUTION A/S (DK) | 2022-01-18 | — | — | US | disclosed |
| EP-3540059-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | Nuevolution A/S (DK) | 2019-09-18 | — | — | EP | disclosed |
| EP-2558577-B1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION AS (DK) | 2018-12-12 | — | — | EP | disclosed |
| US-20130281324-A1 | BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2013-10-24 | — | — | US | disclosed |
| US-RE44048-E1 | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-YL]benzenesulfonamide for the treatment of inflammation or an inflammation-associated disorder | G.D. SEARLE LLC (US) | 2013-03-05 | — | — | US | disclosed |
| US-5466823-A | Antiinflammatory agents; FDA Orange book listed patent for Celebrex | G.D. SEARLE & CO. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5434178-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G.D. SEARLE & CO. (US) | 1995-07-18 | — | — | US | disclosed |
| WO-1995015316-A1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | G. D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |
| US-5264436-A | Alpha-adrenoceptors antagonist, hypotensive agents or antidiabetic agents | BEECHAM GROUP P.L.C. (GB) | 1993-11-23 | — | — | US | disclosed |
| EP-0275639-B1 | N-SUBSTITUTED CYCLIC AMIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1992-07-15 | — | — | EP | disclosed |
| US-5077299-A | Glaucoma, antidepressants, anticoagulants, hypotensive agents | BEECHAM GROUP P.L.C. (GB) | 1991-12-31 | — | — | US | disclosed |
| EP-0372470-A2 | Novel alpha-cyano-beta-oxopropionamides | CIBA-GEIGY AG (CH) | 1990-06-13 | — | — | EP | disclosed |
| US-4918083-A | 4,5 Dihydroimidazole compounds which have useful pharmaceutical utility | BEECHAM GROUP P.L.C. (GB) | 1990-04-17 | — | — | US | disclosed |
| EP-0275639-A1 | N-substituted cyclic amides, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-07-27 | — | — | EP | disclosed |
| CN-85105298-A | 1, the preparation method of 3-dithiole-2-ylidene derivatives | — | 1987-01-28 | — | — | CN | disclosed |