Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.37 |
| ▸ | ARG2 | P78540 | 2/20 | 0.36 |
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181323 | 0.85 | TSHR (0.46) | CYP4F2CYP4A11ARG2ARG1CYP2D6 | |
| SCHEMBL11415606 | 0.81 | TSHR (0.42) | CYP4F2CYP4A11ARG2ARG1CYP2D6 | |
| SCHEMBL7611294 | 0.81 | TSHR (0.42) | CYP4F2CYP4A11ARG2ARG1CYP2D6 | |
| SCHEMBL354517 | 0.79 | CYP4F2 (0.56) | CYP4F2CYP4A11TSHRPPARA | |
| SCHEMBL11435514 | 0.77 | TSHR (0.42) | CYP4F2CYP4A11ARG2ARG1CYP2D6 | |
| SCHEMBL12801895 | 0.75 | CYP4F2 (0.41) | CYP4F2CYP4A11ARG2ARG1CYP2D6 | |
| SCHEMBL11417008 | 0.75 | CYP4F2 (0.41) | CYP4F2CYP4A11ARG2ARG1CYP2D6 | |
| SCHEMBL28387319 | 0.74 | CYP4F2 (0.44) | CYP4F2CYP4A11ARG2ARG1CYP2D6 | |
| SCHEMBL5963133 | 0.74 | CYP2C19 (0.62) | CYP4F2CYP4A11ARG2CYP2D6TSHR | |
| SCHEMBL9550771 | 0.73 | TDP1 (0.35) | CYP4F2CYP4A11ARG2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560976-A1 | FUROPYRIDINE COMPOUNDS AND USES THEREOF | Novartis AG (CH) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011131709-A1 | FUROPYRIDINE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2011-10-27 | — | — | WO | disclosed |