Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.69 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.59 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.47 |
| ▸ | S100A10 | P60903 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859712 | 0.89 | ADORA2A (0.76) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2576233 | 0.84 | ADORA2A (0.48) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2563401 | 0.82 | ADORA2A (1.00) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6217107 | 0.80 | ADORA2A (0.80) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6213678 | 0.80 | ADORA2A (1.00) | ADORA2AADORA1ADORA2B | |
| SCHEMBL3671996 | 0.80 | ADORA2A (0.61) | ADORA2AADORA1 | |
| SCHEMBL6860974 | 0.80 | ADORA2A (0.69) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6215001 | 0.79 | ADORA2A (0.81) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6861178 | 0.78 | ADORA2A (0.69) | ADORA2AADORA1ADORA2B | |
| Hydrochloric Acid SCHEMBL6219814 | 0.78 | ADORA2A (0.79) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192164-B1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RES LTD (GB) | 2005-08-17 | — | — | EP | claimed |
| US-6787541-B1 | MOVEMENT DISORDERS, PARKINSON'S DISEASE | VERNALIS RESEARCH LIMITED (GB) | 2004-09-07 | — | — | US | claimed |
| EP-1192164-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-04-03 | — | — | EP | claimed |
| WO-2001002409-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-01-11 | — | — | WO | claimed |
| WO-2011133696-A2 | METHODS OF SUPPRESSING ATHEROSCLEROSIS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2011-10-27 | — | — | WO | disclosed |
| EP-1192164-B1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RES LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6787541-B1 | MOVEMENT DISORDERS, PARKINSON'S DISEASE | VERNALIS RESEARCH LIMITED (GB) | 2004-09-07 | — | — | US | disclosed |
| EP-1192164-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001002409-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-01-11 | — | — | WO | disclosed |