Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 15/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2565216 | 0.89 | MAP2K1 (0.75) | MAP2K1CYP2C9KCNH2CYP2C19MAP2K2 | |
| SCHEMBL2564424 | 0.87 | MAP2K1 (0.80) | MAP2K1CYP2C9KCNH2CYP2C19PIM1 | |
| SCHEMBL2566733 | 0.86 | MAP2K1 (0.61) | MAP2K1CYP2C9KCNH2CYP2C19PIM1 | |
| SCHEMBL2562947 | 0.84 | MAP2K1 (0.59) | MAP2K1CYP2C9KCNH2CYP2C19PIM1 | |
| SCHEMBL2567751 | 0.84 | MAP2K1 (0.63) | MAP2K1KCNH2MAP2K2 | |
| SCHEMBL2568830 | 0.84 | MAP2K1 (0.63) | MAP2K1KCNH2MAP2K2 | |
| SCHEMBL2568879 | 0.84 | MAP2K1 (0.63) | MAP2K1KCNH2MAP2K2 | |
| SCHEMBL2567945 | 0.84 | MAP2K1 (0.57) | MAP2K1CYP2C9KCNH2CYP2C19MAP2K2 | |
| SCHEMBL2565518 | 0.83 | MAP2K1 (0.58) | MAP2K1CYP2C9KCNH2CYP2C19MAP2K2 | |
| SCHEMBL2563969 | 0.83 | MAP2K1 (0.77) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069354-B1 | Aza-benzofuranyl compounds and methods of use | GENENTECH INC (US) | 2011-11-02 | — | — | EP | claimed |