Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 9/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.38 |
| ▸ | CDK8 | P49336 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30415477 | 0.88 | BCL2 (0.55) | BCL2BCL2L1BCL2A1 | |
| SCHEMBL23323413 | 0.88 | BCL2 (0.55) | BCL2BCL2L1BCL2A1 | |
| SCHEMBL30415103 | 0.86 | BCL2 (0.45) | BCL2BCL2L1CDK8 | |
| SCHEMBL25640548 | 0.86 | BCL2 (0.45) | BCL2BCL2L1CDK8 | |
| SCHEMBL29588538 | 0.83 | BCL2 (0.51) | BCL2BCL2L1CDK8BCL2A1 | |
| SCHEMBL24388073 | 0.83 | BCL2 (0.51) | BCL2BCL2L1CDK8BCL2A1 | |
| SCHEMBL25640575 | 0.83 | CRBN (0.35) | BCL2CRBNDDB1 | |
| SCHEMBL31321339 | 0.81 | BCL2 (0.55) | BCL2BCL2L1BCL2A1 | |
| SCHEMBL24775466 | 0.81 | BCL2 (0.55) | BCL2BCL2L1BCL2A1 | |
| SCHEMBL25204580 | 0.81 | BCL2 (0.47) | BCL2BCL2L1BCL2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478520-B | Bcl-2 protein apoptosis inducer and application thereof | 杭州和正医药有限公司 | 2025-01-10 | — | — | CN | disclosed |
| WO-2023104043-A1 | ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 杭州和正医药有限公司 | 2023-06-15 | — | — | WO | disclosed |
| CN-114478520-A | Bcl-2 protein apoptosis inducer and application thereof | 杭州和正医药有限公司 | 2022-05-13 | — | — | CN | disclosed |