Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 11/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2572273 | 0.83 | MAPT (0.50) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL2574381 | 0.79 | MAPT (0.46) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL2567876 | 0.76 | MAPT (0.53) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL2564351 | 0.74 | KMT2A (0.39) | LMNAHTTALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2572361 | 0.74 | MAPT (0.55) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL2573379 | 0.73 | MAPT (0.51) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL13407309 | 0.71 | MAPT (0.59) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL2573499 | 0.70 | MAPT (0.53) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL2572337 | 0.70 | MAPT (0.53) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL2573075 | 0.69 | MAPT (0.55) | LMNAHTTALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987030-B1 | 3 -DEAZAPURINE DERIVATIVES AS TLR7 MODULATORS | PFIZER LTD (GB) | 2011-11-09 | — | — | EP | disclosed |