Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | JAK1 | P23458 | 3/20 | 0.60 |
| ▸ | TYK2 | P29597 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.60 |
| ▸ | JAK3 | P52333 | 3/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 8/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10224893 | 0.92 | JAK2 (0.58) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL173552 | 0.92 | JAK2 (0.58) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL174030 | 0.92 | JAK2 (0.58) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL174031 | 0.92 | JAK2 (0.58) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL13186839 | 0.87 | JAK2 (0.68) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL188252 | 0.87 | JAK2 (0.68) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL164807 | 0.87 | JAK2 (0.68) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL187661 | 0.86 | JAK2 (0.67) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL10224897 | 0.86 | JAK2 (0.67) | JAK2CYP3A4CYP2C8CYP2C9JAK1 | |
| SCHEMBL255867 | 0.86 | JAK2 (0.67) | JAK2CYP3A4CYP2C8CYP2C9JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030918-A1 | ADENOSINE A3 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |