Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28011393 | 0.81 | GRIN1 (0.57) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL15562785 | 0.79 | GRIN1 (0.53) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL659842 | 0.70 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Hydrochloric Acid SCHEMBL11656331 | 0.69 | GRIN1 (0.95) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL28098360 | 0.68 | GRIN1 (0.41) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL812216 | 0.68 | GRIN1 (0.68) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL28833937 | 0.67 | GRIN2D (0.41) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL7453250 | 0.67 | MEN1 (0.58) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| SCHEMBL733617 | 0.67 | EPHX2 (0.62) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Ammonia Solution, Strong SCHEMBL14695768 | 0.66 | GRIN1 (0.65) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097372-B1 | PROCESS FOR THE PREPARATION OF MEMANTINE AND ITS HYDROCHLORIC ACID SALT FORM | KRKA D D NOVO MESTO (SI) | 2017-05-31 | — | — | EP | claimed |
| EP-2097372-A1 | PROCESS FOR THE PREPARATION OF MEMANTINE AND ITS HYDROCHLORIC ACID SALT FORM | KRKA, D.D., Novo Mesto (SI) | 2009-09-09 | — | — | EP | claimed |
| WO-2008040560-A1 | PROCESS FOR THE PREPARATION OF MEMANTINE AND ITS HYDROCHLORIC ACID SALT FORM | KRKA, D.D., NOVO MESTO (SI) | 2008-04-10 | — | — | WO | claimed |
| EP-1908748-A1 | Process for the preparation of memantine and its hydrochloric acid salt form | KRKA (SI) | 2008-04-09 | — | — | EP | claimed |
| EP-2097372-B1 | PROCESS FOR THE PREPARATION OF MEMANTINE AND ITS HYDROCHLORIC ACID SALT FORM | KRKA D D NOVO MESTO (SI) | 2017-05-31 | — | — | EP | disclosed |
| EP-2555616-A1 | PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE | Hetero Research Foundation (IN) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011125062-A1 | PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE | HETERO RESEARCH FOUNDATION (IN) | 2011-10-13 | — | — | WO | disclosed |
| EP-2097372-A1 | PROCESS FOR THE PREPARATION OF MEMANTINE AND ITS HYDROCHLORIC ACID SALT FORM | KRKA, D.D., Novo Mesto (SI) | 2009-09-09 | — | — | EP | disclosed |
| EP-2097372-A1 | PROCESS FOR THE PREPARATION OF MEMANTINE AND ITS HYDROCHLORIC ACID SALT FORM | KRKA, D.D., Novo Mesto (SI) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008040560-A1 | PROCESS FOR THE PREPARATION OF MEMANTINE AND ITS HYDROCHLORIC ACID SALT FORM | KRKA, D.D., NOVO MESTO (SI) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008040560-A1 | PROCESS FOR THE PREPARATION OF MEMANTINE AND ITS HYDROCHLORIC ACID SALT FORM | KRKA, D.D., NOVO MESTO (SI) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908748-A1 | Process for the preparation of memantine and its hydrochloric acid salt form | KRKA (SI) | 2008-04-09 | — | — | EP | disclosed |
| EP-1908748-A1 | Process for the preparation of memantine and its hydrochloric acid salt form | KRKA (SI) | 2008-04-09 | — | — | EP | disclosed |