SCHEMBL2564604

SCHEMBL2564604

CC(C)(C)OC(=O)NC1CC1c1ccc(N)cc1

nearest known ligand 0.70

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 3/20 0.70
MAOB P27338 2/20 0.61
MAOA P21397 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
TLR2 O60603 4/20 0.41
TLR1 Q15399 4/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
PDE4B Q07343 2/20 0.39
EPHX2 P34913 1/20 0.39
BTK Q06187 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17287408 1.00 KDM1A (0.70) KDM1AMAOBMAOASMN1; SMN2NPSR1
SCHEMBL15235894 0.87 KDM1A (0.71) KDM1AMAOBMAOASMN1; SMN2NPSR1
SCHEMBL15096181 0.87 KDM1A (0.71) KDM1AMAOBMAOASMN1; SMN2NPSR1
SCHEMBL17718446 0.87 KDM1A (0.71) KDM1AMAOBMAOASMN1; SMN2NPSR1
SCHEMBL15099831 0.87 KDM1A (0.71) KDM1AMAOBMAOASMN1; SMN2NPSR1
SCHEMBL13453249 0.87 KDM1A (0.71) KDM1AMAOBMAOASMN1; SMN2NPSR1
SCHEMBL16019177 0.87 KDM1A (0.71) KDM1AMAOBMAOASMN1; SMN2NPSR1
SCHEMBL17718439 0.87 KDM1A (0.71) KDM1AMAOBMAOASMN1; SMN2NPSR1
SCHEMBL17287389 0.86 KDM1A (0.70) KDM1AMAOBMAOASMN1; SMN2NPSR1
SCHEMBL15149989 0.86 KDM1A (0.70) KDM1AMAOBMAOASMN1; SMN2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11565994-B2 Inhibitors of histone lysine specific demethylase (LSD1) and histone deacetylases (HDACS) THE JOHNS HOPKINS UNIVERSITY (US) 2023-01-31 US disclosed
US-20210009511-A1 INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) THE JOHNS HOPKINS UNIVERSITY 2021-01-14 US disclosed
US-10233165-B2 Cyclopropylamine compounds as histone demethylase inhibitors ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2019-03-19 US disclosed
EP-3148974-B1 CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS ST EUROPEO DI ONCOLOGIA S R L (IT) 2018-09-26 EP disclosed
US-20170190680-A1 CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2017-07-06 US disclosed
US-20170029366-A1 INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) THE JOHNS HOPKINS UNIVERSITY (US) 2017-02-02 US disclosed
EP-2560949-B1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 UNIVERSIT DEGLI STUDI DI ROMA LA SAPIENZA (IT) 2015-12-02 EP disclosed
EP-2949648-A1 Cyclopropylamine derivatives as histone demethylase inhibitors IEO - Istituto Europeo di Oncologia Srl (IT) 2015-12-02 EP disclosed
EP-2560949-B1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 UNIVERSIT DEGLI STUDI DI ROMA LA SAPIENZA (IT) 2015-12-02 EP disclosed
WO-2015134973-A1 INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) THE JOHNS HOPKINS UNIVERSITY (US) 2015-09-11 WO disclosed
US-8765820-B2 Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2 Universita Degli Studi Di Roma “La Sapienza” (IT) 2014-07-01 US disclosed
US-8765820-B2 Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2 Universita Degli Studi Di Roma “La Sapienza” (IT) 2014-07-01 US disclosed
US-8765820-B2 Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2 Universita Degli Studi Di Roma “La Sapienza” (IT) 2014-07-01 US disclosed
CN-102985402-A Tranylcypromine derivatives as inhibitors of histone demethylase LSD1 and/or LSD2 UNIV ROMA 2013-03-20 CN disclosed
EP-2560949-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 Università degli Studi di Roma "La Sapienza" (IT) 2013-02-27 EP disclosed
US-20130035377-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) 2013-02-07 US disclosed
US-20130035377-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) 2013-02-07 US disclosed
US-20130035377-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) 2013-02-07 US disclosed
WO-2011131576-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) 2011-10-27 WO disclosed
WO-2011131576-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) 2011-10-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11565994-B2 Inhibitors of histone lysine specific demethylase (LSD1) and histone deacetylases (HDACS) KDM1B, KDM2A, EHMT2 KDM1A 4/4885MAOB 66/4885MAOA 48/4885
US-20210009511-A1 INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) KDM1B, KDM2A, EHMT2 KDM1A 4/4885MAOB 66/4885MAOA 48/4885
US-20170029366-A1 INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) KDM1B, KDM2A, EHMT2 KDM1A 4/4885MAOB 66/4885MAOA 48/4885
US-20130035377-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 KDM1B, KDM2A, KDM3A KDM1A 4/4885MAOB 72/4885MAOA 103/4885
US-10233165-B2 Cyclopropylamine compounds as histone demethylase inhibitors KDM1B, PHF2, KDM6B KDM1A 12/4885MAOB 425/4885MAOA 439/4885
US-20170190680-A1 CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS KDM1B, PHF2, KDM6B KDM1A 12/4885MAOB 425/4885MAOA 439/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.