Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2569333 | 0.85 | MAP2K1 (0.57) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL2565784 | 0.83 | MAP2K1 (0.58) | MAP2K1MAP2K2 | |
| SCHEMBL2562768 | 0.82 | MAP2K1 (0.55) | MAP2K1MAP2K2IDO1CYP2C9CYP2C19 | |
| SCHEMBL2563462 | 0.81 | MAP2K1 (0.54) | MAP2K1MAP2K2IDO1CYP2C9CYP2C19 | |
| SCHEMBL2563469 | 0.81 | MAP2K1 (0.54) | MAP2K1MAP2K2IDO1CYP2C9CYP2C19 | |
| SCHEMBL2563464 | 0.80 | MAP2K1 (0.54) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL2565295 | 0.79 | MAP2K1 (0.57) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL12164526 | 0.78 | MAP2K1 (0.72) | MAP2K1MAP2K2CYP2C9CYP2C19KCNH2 | |
| SCHEMBL2568269 | 0.77 | MAP2K1 (0.59) | MAP2K1MAP2K2CYP2C9CYP2C19KCNH2 | |
| SCHEMBL2565371 | 0.75 | MAP2K1 (0.74) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069354-B1 | Aza-benzofuranyl compounds and methods of use | GENENTECH INC (US) | 2011-11-02 | — | — | EP | claimed |