Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.50 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27809783 | 0.83 | CDK2 (0.53) | CDK2CCNE1CDK5FDPSALDH1A1 | |
| SCHEMBL2139644 | 0.82 | CDK2 (0.51) | CDK2CCNE1CDK5FDPSALDH1A1 | |
| SCHEMBL2628924 | 0.82 | CDK2 (0.51) | CDK2CCNE1CDK5FDPSALDH1A1 | |
| SCHEMBL13130412 | 0.77 | CDK2 (0.51) | CDK2CCNE1CDK5FDPSALDH1A1 | |
| SCHEMBL25093843 | 0.77 | CDK2 (0.51) | CDK2CCNE1CDK5FDPSALDH1A1 | |
| SCHEMBL21401434 | 0.76 | CDK2 (0.50) | CDK2CCNE1CDK5FDPSALDH1A1 | |
| SCHEMBL2140857 | 0.73 | CCNE1 (0.44) | CDK2CCNE1CDK5FDPSALDH1A1 | |
| SCHEMBL3053764 | 0.72 | — | — | |
| SCHEMBL27261630 | 0.70 | — | — | |
| SCHEMBL11597189 | 0.70 | HCAR2 (0.39) | ALDH1A1SMN1; SMN2NPC1RAB9AHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |