Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.44 |
| ▸ | HTR2B | P41595 | 9/20 | 0.39 |
| ▸ | HTR2A | P28223 | 8/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.33 |
| ▸ | PDE4A | P27815 | 5/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2569024 | 0.85 | HTR2C (0.45) | HTR2CHTR2BHTR2APDE10APDE4B | |
| SCHEMBL9948092 | 0.82 | POLB (0.42) | HTR2CPDE10A | |
| SCHEMBL2570142 | 0.81 | MEN1 (0.47) | — | |
| SCHEMBL2574852 | 0.79 | HTR2C (0.43) | HTR2CHTR2BHTR2A | |
| SCHEMBL2574854 | 0.79 | HTR2C (0.40) | HTR2CHTR2BHTR2APDE4BPDE4D | |
| SCHEMBL4955234 | 0.77 | HTR2C (0.46) | HTR2CHTR2BHTR2APDE10A | |
| SCHEMBL4956864 | 0.77 | HTR2C (0.46) | HTR2CHTR2BHTR2APDE10A | |
| SCHEMBL4955735 | 0.76 | HTR2C (0.47) | HTR2CHTR2BHTR2APDE10A | |
| SCHEMBL2570503 | 0.76 | HTR2C (0.58) | HTR2CHTR2BHTR2A | |
| SCHEMBL2573429 | 0.76 | HTR2C (0.50) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384328-A1 | 6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR PREPARING THEM | Boehringer Ingelheim International GmbH (DE) | 2011-11-09 | — | — | EP | disclosed |
| WO-2010060952-A1 | 6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |