⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13978281 | 0.73 | — | — | |
| SCHEMBL13978284 | 0.69 | TSHR (0.31) | — | |
| SCHEMBL3726084 | 0.68 | — | — | |
| SCHEMBL562875 | 0.67 | — | — | |
| SCHEMBL112772 | 0.67 | — | — | |
| SCHEMBL18194736 | 0.65 | — | — | |
| SCHEMBL10805641 | 0.65 | — | — | |
| SCHEMBL15935826 | 0.65 | — | — | |
| SCHEMBL587919 | 0.65 | — | — | |
| SCHEMBL11621620 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230190785-A1 | COMPOSITIONS AND METHODS FOR SILENCING DNAJC15 GENE EXPRESSION | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230183707-A1 | COMPOSITIONS AND METHODS FOR INHIBITING MARC1 GENE EXPRESSION | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-06-15 | — | — | US | disclosed |